🧬 Regenerative Aesthetics and the Difference Between Platelet vs. Amniotic Exosomes. I’m Using Amniotic Exosomes To Heal From Fraxel Laser.
What two of the smartest people in regenerative medicine taught me about cell signaling, why I still get Fraxel, and the experiment I'm running on my own face this August.
Click the ❤️ if you agree that beautiful aging is energetic aging—and that we’re never too old to love beauty.
Hey Darling,
I turned 65 this month.
I still love beauty. That has not changed since I was a girl putting on my mom’s makeup in the bathroom mirror. What has changed is my definition of it.
Beautiful skin, to me, is healthy skin. Beautiful aging is energetic aging. The women and men I admire most are the ones who radiate health from inside… Good skin, strong muscles, healthy smiles, clear eyes, shiny hair, full of passionate ideas, and a bounce in their step.
That glow comes from four places I pay attention to every single day. Strength training. Deep, restorative sleep. Nutrient-dense food. And glorious, regular orgasmic intimacy. I’ve written about all four for years, because I believe they do more for my skin than any cream sitting on my bathroom counter.
Yet I still love the latest in skincare. One of my recent articles was about biobarrier creams and the new era of regenerative skin care:
🙂↕️ Stem Cells, Exosomes, and PRP for Skin Care and Anti-Aging Explained. Plus, Why A Simple Barrier Cream Is Tremendously Beneficial As You Age
I’ve had plastic surgery. And about every other year, I lie down for a deep Fraxel CO2 laser resurfacing treatment to keep the positive effects of that surgery working well. I laser my face, neck, chest, arms, and the backs of my hands because I love biking and swimming in the ocean so much that I am managing the spots and texture from sun exposure.
Here is what I want to tell you today. I have been listening to two brilliant people discuss a completely different way of thinking about skin, which has illuminated my understanding of regenerative aesthetics.
One is Alyssa Lask, CEO of Rion Aesthetics and Plated Skin Science, interviewed by David Stewart on the AGEIST Podcast. The other is my own regenerative medicine physician, Dr. Jeff Gross, whose ExoAgeless educational webinar I watched start to finish.
Neither of them talked about wrinkle creams. They talked about cell signaling. By the end of this piece, you’ll understand what exosomes are, why two very different companies are chasing the same biology from opposite directions, and why I’m pairing one of these products with my own Fraxel treatment this August. Let’s get into it.
From Fixing Skin To Talking To It
For decades, aesthetic medicine has mostly asked one question. How do we make skin look younger? Moisturize it. Plump it. Freeze it. Resurface it. Fill it.
I’ve benefited from several of those approaches myself, and I’ll keep using them.
But regenerative medicine is asking a different question now, one I find far more compelling. How do we help the cells we already have behave the way they did when we were young? That single shift, from correcting the surface to instructing the cell, changed how I think about my entire skincare routine.
The Text Message Analogy That Made It Click
You’ve probably heard the word exosome floating around. Maybe alongside stem cells, PRP, peptides, growth factors, and salmon DNA facials. It becomes alphabet soup fast.
Alyssa Lask gave the clearest explanation I’ve ever heard. She described exosomes as the texting system of the body, the way one cell reaches another and tells it what to do next.
Some of those texts carry a signal for inflammation. Some carry a signal for cell death. And some carry a very specific message: renew, repair, build collagen, and act younger.
Stem cells, it turns out, may not be doing most of the healing directly. They’re dispatching instructions, and exosomes are one of the couriers carrying that instruction set to the surrounding tissue.
Alyssa’s team builds their product, Plated, around platelet-derived exosomes. Her logic is straightforward. Platelets are your body’s first responders. Cut your hand, and platelets rush to the wound before anything else arrives. Repair is their entire job description, so the exosomes they release are already fluent in the language of healing.
I started my first regenerative treatments with PRP, which is platelet-rich plasma. My first regenerative doctor, Robyn Benson, DOM, gave me O Shots (Orgasm Shots) into my clitoris made from parts of my own blood. These regenerated the tissue to prevent atrophy and loss of sensation. Consider PRP and its cousin, PRF, to be the 1.0 of regenerative therapy.
Renew The Cell, Don’t Just Cover It
Dr. Jeff Gross of ReCELLebrate—my current regenerative doctor—took the idea one layer deeper for me. He described regeneration not as replacing tissue, but as coaxing older cells to behave like younger ones again.
That reframe was spot on because it’s how I already think about longevity. Every day I’m working to lower inflammation, improve my gut health, keep my biomes in tip-top shape, track my blood markers and support my mitochondria, sleep well, lift weights, eat real food, and have wonderful sex, because all of those are signals telling my body to keep functioning as it did a decade ago. Why wouldn’t my skin get the same instructions?
Dr. Gross’s product, ExoAgeless Revival Biocream, takes a different biological path than Plated. Where Alyssa’s company draws from platelets, his draws from amniotic fluid, the growth factors, and exosomes found in one of nature’s most regenerative environments. Pregnant women often glow, their hair thickens, and their skin heals fast. His formulation is built to bring a version of that signaling environment to a topical cream.
And it is bottled at the source from highly screened, non-Covid vaccinated mothers undergoing C-section and right onto ice on the spot. It is never powdered (lyophilized) or allowed to get warm. It never sees the inside of a flask where it is coaxed to divide or produce. Although filtered and tested, it is au nautrale. Unlike all other skin products, ExoAgeless is shipped on ice and kept refrigerated to avoid the use of preservatives.
Two different sources. Two different scientific bets. Both support the same greater idea, that skin can be spoken to rather than simply resurfaced.
Regenerative Skin Care Comparison Table
Here’s how I now organize the technologies that get lumped together under “regenerative skincare,” because the differences matter.
Why I Still Show Up For Fraxel
People are surprised when I tell them I go under for a deep Fraxel CO2 treatment every other year. It sounds dramatic, and it is.
The laser creates thousands of microscopic columns of controlled injury across the skin. They look like pin dots because Fraxel is a fractional laser. It doesn’t damage ALL the tissue. It damages a percentage of it.
The laser itself isn’t the magic. The magic is what your body does next. Fibroblasts wake up, collagen production climbs, and older damaged tissue gets rebuilt from underneath. Fraxel is a build back better strategy for aging tissue.
Dr. Gross put words to something I’d felt intuitively for years. He said regenerative medicine is moving from hurt it so it heals, to tell it to renew directly. Fraxel triggers the repair cascade through injury. A regenerative topical may support the same renewal signal without needing the injury at all. Used together, one primes the terrain, and the other accelerates the healing that follows.
That is elegant biology, and it’s exactly the kind of thing that gets me curious enough to test on my own face. That and my deep trust in the work Dr. Gross does. If you haven’t seen the video series we’ve done together, fixing my torn ACL’s and MCL’s; helping heal me from COVID, including regrowing my lost hair; and doing the first stem cell O Shot ever, they are here:
My Own Experiment, In Full View
Here’s exactly where I stand, and I want to be exacting about it because I take my credibility with you seriously.
I believe in regenerative medicine. I’ve had genuinely positive personal experiences with stem cells and exosome therapies under Dr. Gross’s care, in areas well beyond skin. I find the emerging science around topical exosomes intriguing enough to follow closely.
So this August, ahead of my every-other-year Fraxel treatment, I’m using ExoAgeless to prepare my skin, and I’ll continue using it during recovery once my physician clears me for active skincare again. I’m doing this because the biological rationale makes sense to me, not because I already know the outcome. My face is the experiment, and I’ll report back exactly what I see.
I want to be transparent about something else too. I’m not an affiliate, and this isn’t sponsored content. What I have that’s worth more to me than a commission is your trust. I read the research, I talk to the physicians doing the work, I compare competing approaches honestly, and then I try things on myself before I ever suggest you consider them. That’s the whole reason you keep reading Longevity Wins, and I don’t take it lightly. I try a lot of things that never make it to print.
What You Learned Today
Regenerative skincare is shifting the goal from covering up aging to improving cellular signaling.
Exosomes act like biological text messages, carrying instructions between cells, including specific signals for renewal and repair.
Platelets are the body’s first responders to injury, which is why platelet-derived exosomes carry a natural repair instruction set.
Fraxel works by creating controlled injury that activates your body’s own healing cascade.
Amniotic-derived exosomes take a different and more active biological path, drawing on nature’s most regenerative environment—creation.
I’m personally testing ExoAgeless around my upcoming Fraxel treatment because the science persuades me, not because I have proof of the outcome yet.
I’d Love To Hear From You
Have you tried Fraxel or another resurfacing treatment? Would you experiment with regenerative skincare? Does the science of exosomes excite you, or does it still feel like it belongs in a science fiction novel?
Comment, please. I read every single one.
If this piece helped you see a new frontier in longevity and beauty, tap the heart, share it with a friend who obsesses over healthy aging the way you do, and subscribe if you haven’t yet. I want you with me as I keep exploring how we can extend both our health span and our beauty span.
To your healthspan and beauty span,
Suz
Sources
This article grew out of two excellent interviews I studied closely.
Dr. Jeff Gross’s ExoAgeless educational webinar through Recellebrate
This article reflects my own research and personal experience. It is not medical advice. Regenerative therapies continue to evolve, and I encourage you to discuss any aesthetic procedure or skincare decision with your own qualified healthcare provider.
P.S. Somewhere between the platelets and the placenta, my skin found out it’s been getting instructions its whole life. I just finally learned how to read the message.